Dr. KATALIN E. KÖVÉR

full professor

 

 

University of Debrecen
Department of Inorganic and Analytical Chemistry
Debrecen, Hungary

 

flag A magyar változathoz kattintson a zászlóra.                                         

 


Office address:       University of Debrecen, Department of Inorganic and Analytical Chemistry
                                               H-4010 Debrecen P.O.Box 21, Hungary
                                               telephone: + 36 52 512900 ext.: 22370
                                               fax: + 36 52 489667
                                               e-mail: kover@tigris.unideb.hu



Academic degrees:

1979

M.Sc. in chemistry, Lajos Kossuth University, Debrecen, Hungary

1984Ph.D. Lajos Kossuth University, Debrecen, Hungary
1988C.Sc. (Candidate of Sciences), Hungarian Academy of Sciences
2002  D.Sc. (Doctor of Sciences), Hungarian Academy of Sciences
 

Professional career:

1979-84   Research Fellow (BIOGAL Pharmaceutical Works - Department of  Organic Chemistry,                                        L. Kossuth University, Debrecen)
1984-88   Research Associate (BIOGAL Pharmaceutical Works - Department of  Organic Chemistry,                                    L. Kossuth University, Debrecen)
1988-96   Senior Research Associate (BIOGAL Pharmaceutical Works - Department of  Organic Chemistry,                         L. Kossuth University, Debrecen)
1996-99   Senior Research Associate (Department of  Organic Chemistry,                                                                              L. Kossuth University, Debrecen)
1999-2003    Senior Research Associate (Department of  Inorganic and Analytical Chemistry,                                          University of Debrecen, Debrecen)
2003-2008  Distinguished Researcher (Department of  Inorganic and Analytical Chemistry,                                                 University of Debrecen, Debrecen)
2008-   Full Professor (Department of  Inorganic and Analytical Chemistry,                                                          University of Debrecen, Debrecen)

 

Professional trips:

1987  

University of Illinois, Department of Biochemistry, Chicago, USA

1991-1993  Department of Chemistry, The University of Arizona, USA
1995Department of Chemistry, University of Arizona, Tucson, USA
1997Department of Chemistry, University of Arizona, Tucson, USA
1998

Departamento de Espectroscopia y Estructura Molecular. Instituto de Quimica Fisica "Rocasolano". CSIC, Madrid, Spain

1999

Department of Inorganic, Physical and Structural Chemistry

visiting professor, Stockholm University, Sweden

1999Department of Chemistry, University of Arizona, Tucson, USA
2002MTA-OTKA-NSF, Department of Chemistry, University of Arizona, Tucson, USA
2003Stockholm University, Department of Physico-Chemistry, Sweden
2004, 2005University of Cape Town, Department of Computation Chemistry, Cape Town, South Africa
2005CSIC, Madrid, Spain
2006Department of Chemistry, University of Arizona, Tucson, USA

 

Awards:

 

Erdey L. Award from the Hungarian Academy of Sciences for NMR methodological developments, 1986
Széchenyi fellow from the Ministry of Education, Hungary, 1998-2001
 


Membership of Professional Societies:

          

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Research interest

 

 

 

 

 

Current research topics

 

    NMR methodological developments: design of sensitivity enhanced gradient experiments for the measurement of homo- and heteronuclear

       coupling constants, relaxation rates and relaxation interference effects. Residual dipolar coupling constant (RDC).

 

    NMR of biologically active oligopeptides and oligosaccharides.

 

    NMR structure and dynamic study of proteins. Receptor-ligand interactions. Application of TROSY-approach.

 

    Ligand-protein interactions studied by transferred NMR experiments.

 

Number of publications: 148                    

Number of independent citations: 1238

 

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Recent selected publications:

1.M. D. Shenderovich, K. E. Kövér, G. V. Nikiforovich, D. Jiao, V. J. Hruby
Conformational Analysis of b-Methyl-para-nitrophenylalanine Stereoisomers of [Cyclo(D-Pen2, D-Pen5)]enkephalin by NMR Spectroscopy and Conformational Energy Calculations
Biopolymers 1996, 38, 141.
2.G. V. Nikiforovich, K. E. Kövér, S. A. Kolodziej, B. Nock, C. George, J. R. Deschamps, J. L. Flippen-Anderson, G. R. Marshall
Design and Comprehensive Conformational Studies of Tyr1-cyclo(D-Pen2-Gly3-Phe4-L-3-Mpt5) and Tyr1-cyclo(D-Pen2-Gly3-Phe4-D-3-Mpt5): Novel Conformationally Constrained Opioid Peptides
J. Amer. Chem. Soc. 1996, 118, 959.
3.Gy. Batta, K. E. Kövér, J. Gervay, M. Hornyák, G. M. Roberts
Temperature Dependence of Molecular Conformation, Dynamics, and Chemical Shift Anisotropy of a,a-Trehalose in D2O by NMR Relaxation
J. Amer. Chem. Soc. 1997, 119, 1336.
4.M. D. Shenderovich, K. E. Kövér, S. Wilke, N. Collins, V. J. Hruby
Solution Conformations of Potent Bicyclic Antagonists of Oxytocin by Nuclear Magnetic Resonance Spectroscopy and Molecular Dynamics Simulations
J. Amer. Chem. Soc. 1997, 119, 5833.
5.K. E. Kövér, V. J. Hruby, D. Uhrin
Sensitivity and Gradient Enhanced Heteronuclear Coupled/Decoupled HSQC-TOCSY Experiments for Measuring Long-Range Heteronuclear Coupling Constants
J. Magn. Reson. 1997, 129, 125.
6.K. E. Kövér, D. Uhrin, V. J. Hruby
Gradient- and Sensitivity-Enhanced TOCSY Experiments
J. Magn. Reson. 1998, 130, 162.
7.Gy. Batta, K. E. Kövér, J. Kowalewski
A Comparison of 1D and 2D (unbiased) experimental methods for measuring the CSA/DD cross-correlated relaxation
J. Magn. Reson. 1999, 136, 37.
8.K. E. Kövér, Gy. Batta
A General Scheme for Suppression of ABX Strong Coupling Signals in Heteronuclear Scalar and Dipolar Correlation Experiments
J. Magn. Reson. 1999, 138, 89.
9.     K. E. Kövér, K. Fehér, L. Szilágyi, A. Borbás, P. Herczegh, A. Lipták
2D NMR spectra of oligosaccharides enhanced by band-selective suppression of unwanted signals
Tetr. Lett. 2000, 41, 393.
10. K. E. Kövér, Gy. Batta

Separating Structure and Dynamics in CSA/DD Cross-Correlated Relaxation: A Case Study on Trehalose and Ubiquitin

J. Magn. Reson. 2001, 150, 137.
11. K. E. Kövér, Gy. Batta

J-modulated TROSY experiment (TROSY-JM) extends the limits of homonuclear coupling measurements for larger proteins

J. Magn. Reson. 2001, 151, 60.
12. K. Fehér, S. Berger, K. E. Kövér

Accurate determination of small one-bond heteronuclear residual dipolar couplings by F1 coupled HSQC modified with a G-BIRD(r) module

J. Magn. Reson. 2003, 163, 340.
13. K. E. Kövér, P. Forgó

J-modulated ADEQUATE (JM-ADEQUATE) experiment for accurate measurement of carbon-carbon coupling constants

J. Magn. Reson. 2004, 166, 47.
14. K. E. Kövér, Gy. Batta, J. Kowalewski, Leila Ghalebani and Danuta Kruk

Internal dynamics of hydroxymethyl rotation from CH2 cross-correlated dipolar relaxation in methyl-b-D-glucopyranoside

J. Magn. Reson. 2004, 167, 273.
15. K. E. Kövér, K. Fehér

Measurement of one-bond heteronuclear dipolar coupling contributions for amine and diastereotopic methylene protons

J. Magn. Reson. 2004, 168, 307.
16. T. N. Pham, K. E. Kövér, L. Jin and D. Uhrín

1H-Detected Double-J-Modulated INEPT-INADEQUATE for simultaneous determination of one-bond and long-range carbon-carbon connectivities and the measurement of all carbon-carbon coupling constants

J. Magn. Reson. 2005, 176, 199.
17. K. E. Kövér, Gy. Batta and K. Fehér

Accurate measurement of long-range heteronuclear coupling constants from undistorted multiplets of an enhanced CPMG-HSQMBC experiment

J. Magn. Reson. 2006, 181, 89.
18. K. E. Kövér, P. Groves, J. Jimenez-Barbero and G. Batta

 Molecular Recognition and Screening Using a 15N Group Selective STD NMR Method

J. Amer. Chem. Soc. 2007, 129, 11579.
19. K. Fehér, P. Groves, Gy. Batta, J. Jiménez-Barbero, C. Muhle-Goll and K. E. Kövér

Application of isotope edited and filtered STD NMR experiments for ligands with overlapping signals in ligand-protein affinity measurements

J. Amer. Chem. Soc. 2008, 130, 17148.
20. K. E. Kövér, M. Bruix, J. Santoro, G. Batta, D.V. Laurents and M. Rico

The solution structure and dynamics of Human Pancreatic Ribonuclease determined by NMR spectroscopy provide insight into its remarkable biological activities and inhibition

J. Mol. Biol. 2008, 379, 953.
21. K. E. Kövér, A. Lipták, T. Beke and A. Perczel

Combined NMR three-bond scalar coupling measurements and QM calculations to calculate OH-rotamer equilibrium of polyalcohols

J. Comput. Chem. 2009, 30, 540.
22. K. Pénzes, K. E. Kövér, F. Fazakas, G. Haramura and L. Muszbek

Molecular mechanism of the interaction between activated factor XIII and its glutamine donor peptide substrate

Journal of Thrombosis and Haemostasis 2009, 7, 627.




Last update: 2 May 2009

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